NONSTEROIDAL TREATMENT OF AUTOIMMUNE SKIN DISEASES
Identifieur interne : 002877 ( Main/Exploration ); précédent : 002876; suivant : 002878NONSTEROIDAL TREATMENT OF AUTOIMMUNE SKIN DISEASES
Auteurs : David P. FivensonSource :
- Dermatologic Clinics [ 0733-8635 ] ; 1997.
English descriptors
- Teeft :
- Acad, Acad dermatol, Acquisita, Antimalarial, Arch dermatol, Autoimmune, Autoimmune skin diseases, Azathioprine, Bullosa, Bullous, Bullous pemphigoid, Caveat, Cicatricial, Cicatricial pemphigoid, Clofazimine, Colchicine, Connective tissue disease, Corticosteroid, Cutaneous, Cyclophosphamide, Cyclosporine, Dapsone, Dermatitis, Dermatitis herpetiformis, Dermatol, Dermatologic, Dermatologic therapy, Dermatomyositis, Dermatosis, Differential count, Discoid, Drug caveat, Drug caveats, Epidermolysis, Epidermolysis bullosa acquisita, Erythema, Erythema elevatum diutinum, Erythematosus, Fivenson, Fivenson table, Gangrenosum, Herpetiformis, Hydroxychloroquine, Laboratory monitoring, Lupus, Lupus erythematosus, Methotrexate, Months drug caveat, Nicotinamide, Nonsteroidal, Nonsteroidal treatment, Pemphigoid, Pemphigus, Pemphigus vegetans, Plasmapheresis, Prednisone, Primary therapy, Pyoderma gangrenosum, Side effects, Subacute, Subacute cutaneous, Syndrome, Systemic, Systemic corticosteroids, Tetracycline, Thalidomide, Therapeutic ladder, Therapeutic ladders, Vasculitis.
Abstract
Treatment of the autoimmune skin diseases (eg, pemphigoid, pemphigus, lupus, vasculitis, among others) can be extremely challenging and frustrating. It can also be quite rewarding to both clinician and patient to find an effective therapeutic regimen to control these chronic diseases. Although many of these diseases can, and should, be effectively treated with corticosteroids, corticosteroid-sparing regimens are increasingly important in the long-term management of these patients. Chronic corticosteroid side effects are well known and include osteoporosis, cataracts, glucose intolerance, obesity, myopathy, glaucoma, depressed wound healing, gastrointestinal ulceration, and so forth.8,28 In this overview, I highlight a variety of therapeutic ladders that I and others have found useful in managing these families of autoimmune skin disease. Although this is certainly not an all inclusive review, the goal for this article is to provide an aid that allows the practicing clinician to feel comfortable applying corticosteroid-sparing treatment approaches to the majority of the patients presenting with an autoimmune cutaneous disorder.
Url:
DOI: 10.1016/S0733-8635(05)70479-4
Affiliations:
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Le document en format XML
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<term>Acad dermatol</term>
<term>Acquisita</term>
<term>Antimalarial</term>
<term>Arch dermatol</term>
<term>Autoimmune</term>
<term>Autoimmune skin diseases</term>
<term>Azathioprine</term>
<term>Bullosa</term>
<term>Bullous</term>
<term>Bullous pemphigoid</term>
<term>Caveat</term>
<term>Cicatricial</term>
<term>Cicatricial pemphigoid</term>
<term>Clofazimine</term>
<term>Colchicine</term>
<term>Connective tissue disease</term>
<term>Corticosteroid</term>
<term>Cutaneous</term>
<term>Cyclophosphamide</term>
<term>Cyclosporine</term>
<term>Dapsone</term>
<term>Dermatitis</term>
<term>Dermatitis herpetiformis</term>
<term>Dermatol</term>
<term>Dermatologic</term>
<term>Dermatologic therapy</term>
<term>Dermatomyositis</term>
<term>Dermatosis</term>
<term>Differential count</term>
<term>Discoid</term>
<term>Drug caveat</term>
<term>Drug caveats</term>
<term>Epidermolysis</term>
<term>Epidermolysis bullosa acquisita</term>
<term>Erythema</term>
<term>Erythema elevatum diutinum</term>
<term>Erythematosus</term>
<term>Fivenson</term>
<term>Fivenson table</term>
<term>Gangrenosum</term>
<term>Herpetiformis</term>
<term>Hydroxychloroquine</term>
<term>Laboratory monitoring</term>
<term>Lupus</term>
<term>Lupus erythematosus</term>
<term>Methotrexate</term>
<term>Months drug caveat</term>
<term>Nicotinamide</term>
<term>Nonsteroidal</term>
<term>Nonsteroidal treatment</term>
<term>Pemphigoid</term>
<term>Pemphigus</term>
<term>Pemphigus vegetans</term>
<term>Plasmapheresis</term>
<term>Prednisone</term>
<term>Primary therapy</term>
<term>Pyoderma gangrenosum</term>
<term>Side effects</term>
<term>Subacute</term>
<term>Subacute cutaneous</term>
<term>Syndrome</term>
<term>Systemic</term>
<term>Systemic corticosteroids</term>
<term>Tetracycline</term>
<term>Thalidomide</term>
<term>Therapeutic ladder</term>
<term>Therapeutic ladders</term>
<term>Vasculitis</term>
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<front><div type="abstract">Treatment of the autoimmune skin diseases (eg, pemphigoid, pemphigus, lupus, vasculitis, among others) can be extremely challenging and frustrating. It can also be quite rewarding to both clinician and patient to find an effective therapeutic regimen to control these chronic diseases. Although many of these diseases can, and should, be effectively treated with corticosteroids, corticosteroid-sparing regimens are increasingly important in the long-term management of these patients. Chronic corticosteroid side effects are well known and include osteoporosis, cataracts, glucose intolerance, obesity, myopathy, glaucoma, depressed wound healing, gastrointestinal ulceration, and so forth.8,28 In this overview, I highlight a variety of therapeutic ladders that I and others have found useful in managing these families of autoimmune skin disease. Although this is certainly not an all inclusive review, the goal for this article is to provide an aid that allows the practicing clinician to feel comfortable applying corticosteroid-sparing treatment approaches to the majority of the patients presenting with an autoimmune cutaneous disorder.</div>
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